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GraphPad Software Inc
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PrimerDesign Inc
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Sony
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BioDiscovery Inc
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BioTuring Inc
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Becton Dickinson
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Rosetta Biosoftware
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Microarrays Inc
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GraphPad Software Inc
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Image Search Results
Journal: International Journal of Biological Sciences
Article Title: Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer
doi: 10.7150/ijbs.18834
Figure Lengend Snippet: Combination of HDAC6 and HSP90 inhibition showed synergistic effect on ERα+ BC T47D cells
Article Snippet: Comparison of
Techniques: Inhibition
Journal: International Journal of Biological Sciences
Article Title: Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer
doi: 10.7150/ijbs.18834
Figure Lengend Snippet: Effects on microtubule cytoskeleton network stabilization of breast cancer cells upon inhibition of HSP90 or HDAC6 or both HSP90 and HDAC6. A. Treatment of 0.1μM 17-DMAG for 24 hours decreased HDAC6 protein level in both ERα+ breast cancer cells and TNBC cells. B. Inhibition of HSP90-HDAC6 with 0.1μM 17-DMAG and 1μM Tubacin increased tubulin acetylation synergistically. C. HSP90/HDAC6 inhibition with 0.1μM 17-DMAG and 1μM Tubacin decreased cell migration in both ERα+ breast cancer cells and TNBC cells. D/E. Analysis and comparison the effects on microtubule cytoskeleton stability in breast cancer cells upon inhibition of HSP90 or HDAC6 or both HSP90 and HDAC6. Each group was compared with control group, *P<0.05.
Article Snippet: Comparison of
Techniques: Inhibition, Migration, Comparison, Control
Journal: International Journal of Biological Sciences
Article Title: Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer
doi: 10.7150/ijbs.18834
Figure Lengend Snippet: Effects on ERK, AKT and Hippo pathway in breast cancer cells upon inhibition of HSP90. A. Investigation of AKT (p-AKT), ERK (p-ERK), and YAP (p-YAP) levels in TNBC cells and ERα positive breast cancer cells upon 0.1μM and 1μM HSP90 inhibitor 17-DMAG treatment. B. Inhibition of HDAC6 with 1μM Tubacin led to a decrease of YAP with an increase in tubulin acetylation, AKT and ERK phosphorylation. C. Effects on cell viability of breast cancer cells upon YAP silencing using siRNAs. Each group was compared to control group, *P<0.05.
Article Snippet: Comparison of
Techniques: Inhibition, Phospho-proteomics, Control
Journal: International Journal of Biological Sciences
Article Title: Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer
doi: 10.7150/ijbs.18834
Figure Lengend Snippet: Effects on HDAC6 expression in breast cancer cells upon inhibition or depletion ERα and in tamoxifen-resistant breast cancer cells A. Inhibition of ERα with 1μM tamoxifen or 0.1μM fulvestrant for 24 hours up-regulated HDAC6 at protein level in ERα positive breast cancer cells. B. Silencing ERα with siRNA elevated HDAC6 protein levelin ERα+ breast cancer cells. C. Inhibition of ERα with 1μM tamoxifen or 0.1μM fulvestrant for 24 hours elevated YAP expression at protein level. D. Higher HDAC6 and YAP expression with lower ERα and acetylated tubulin in T47D-TAR cells compared to those in their parental T47D cells.
Article Snippet: Comparison of
Techniques: Expressing, Inhibition
Journal: International Journal of Biological Sciences
Article Title: Targeting HSP90-HDAC6 Regulating Network Implicates Precision Treatment of Breast Cancer
doi: 10.7150/ijbs.18834
Figure Lengend Snippet: Proposed model for the mechanism of HSP90-HDAC6 regulating network and implication in breast cancer treatment A-C. Proposed molecular mechanism driving breast cancer cells sensitive to HSP90 inhibition and HDAC6 inhibition. D. HSP90 inhibitor 17-DMAG inhibited tumor growth in TNBC cell xenograft mouse model. E. HDAC6 inhibitor Tubacin inhibited tumor growth in tamoxifen-resistant breast cancer cell xenograft mouse model. Each group was compared with control group, *P<0.05.
Article Snippet: Comparison of
Techniques: Inhibition, Control